FundingThe authors received no financial support for the research, authorship, and/or publication of this article.

Clipboard, Search History, and several other advanced features are temporarily unavailable. 651 Dongfeng Eastern Road, Guangzhou, Guangdong, 510060, China, https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (. Filmmaker Brian Knappenberger investigates the tragic death of an 8-year-old California boy who endured horrific abuse by his mother and her boyfriend, along with the fractured and complex systems that failed to protect him. We required trials to report the hazard ratios (HRs) for OS and PFS and/or odds ratios (ORs) for ORR and DCR. Take your favorite fandoms with you and never miss a beat. Follow me on Twitter, YouTube and Instagram. Get the latest from JAMA Internal Medicine. Survivors worldwide reveal the manipulation, abuse and emotional scars suffered at the hands of wealthy convicted pedophile Jeffrey Epstein. Meaning  Login failed.

For each meta-analysis, we applied an internal validation through leave-one-out analysis to evaluate the prediction accuracy of the surrogate model.17 Each trial was left out once, and the surrogate model was built with other trials. The rapid advances in anti-PD-1/PD-L1 therapy for melanoma has spurred researchers and physicians to explore more effective therapies to further extend the clinical benefit; however, a critical issue that is still under investigation is what is the optimal endpoint and how should tumour response be evaluated in anti-PD-1/PD-L1 trials for metastatic melanoma. For data extraction, all studies were reviewed by 2 independent investigators, and disagreements were resolved by a third investigator in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses guideline. Surprisingly, we identified a strong correlation between PFS and OS, which was further verified through extensive sensitivity analyses and leave-one-out cross-validation. STE is an alternative measure for surrogate endpoint validation.16 Using a surrogate endpoint with an STE closer to 1, it would be easier to predict an OS benefit. (A) The blue line represents the 95% prediction limit of the regression line (red line). Well, we started low card farming. Identify all potential conflicts of interest that might be relevant to your comment. Percutaneous coronary intervention was associated with higher all-cause, cardiac, and noncardiac mortality compared with CABG at 5 years.

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