00:41:59.07 the cool, cool chemistry that they do, 00:16:26.10 which is something like an ɑ4β4. 00:09:22.13 and being retired, he had a lot of time on his hands. 00:02:30.28 we have metals that are known to bind to proteins 00:22:30.25 If you don't have the radical you can't do chemistry, 00:15:50.03 And most people have heard of radical-based chemistry,

These results suggest that marine biogeochemical cycles and marine bioinorganic chemistry have co-evolved, and that the evidence for this co-evolution has been preserved in the physiology and genomes of modern descendants of the early cyanobacteria. 00:12:17.05 you need to have a metal. Strikingly, in Mn2+-activated cGAS, the linear intermediates pppGpG and pGpA take an inverted orientation in the active pocket, suggesting a noncanonical but accelerated cGAMP cyclization without substrate flip-over.

(2011) Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase. 00:02:42.13 and metalloproteins that are important for the environment. 00:29:24.23 in the direction it needs to go. 00:26:12.20 and our SAXS data 00:23:06.19 For example, maybe we could 00:39:53.24 collect a little data,

00:26:29.28 ATP pushes is back. 00:12:55.26 but luckily he only told our neighbors, 00:04:20.13 and turn it into biofuels. 00:31:33.01 and that can help you solve what crystallographers call 00:40:00.26 So that can be complicated. 00:10:45.06 most of the things that will kill a bacterial RNR

00:14:15.29 formed because of those beautiful d orbitals, 00:22:53.03 If you're gonna do radical transfer, 00:09:02.08 it can lead to serious disease here. 00:36:23.12 so instead of seeing those beautiful diffraction spots, 00:32:53.16 will depend on the resolution of our structure. 00:41:40.18 But when you do things carefully, 00:29:30.22 down even farther toward the B12. 00:31:48.06 that went into bringing together these multiple techniques 00:19:47.07 You want enough iron, but not too much iron. 00:24:21.27 So, maybe it's because we didn't have folic acid 00:21:37.06 but he took some of his crystals in the glovebox. The weak nephelauxetic effect of water as a ligand contributes to the emergence of the Irving-Williams order of stability in complexing reactions of Mn2+ --> Zn2+ ions in aqueous solution.

00:23:04.27 So that's what you see in solution. 00:41:31.18 and they should show the same number of molecules, 00:28:32.16 So it seems the final movement 00:04:08.13 is that these metallocenters are oxygen sensitive, 00:09:59.05 He said, "In a paper, you always must define every term." 00:22:31.10 and here's the spectra we would expect for that. 00:16:37.03 So biotin synthase, again, uses this cofactor. 00:25:29.26 you can have complete rings, 00:22:07.17 and took it out of the anaerobic chamber 00:16:22.19 Does something move? 00:13:09.16 and I'm telling you this for a reason, 00:06:05.06 in collaboration with Francisco Asturias 00:04:37.14 you need to get the radical from here up to here. 00:12:49.06 you put your protein molecules 00:12:57.06 that's where you have d orbitals. 00:13:22.22 between the methyltransferase β-Propeller structures provide a large flat surface that is thought to be involved in protein–protein interactions. 00:01:47.00 and in part two of the series, 00:27:26.24 You see a ring, you're like, 00:03:42.21 in part one of the talk. 00:32:22.27 for his entire career. 00:15:15.18 now remember dATP downregulates and inhibits the enzyme, 00:19:14.22 of ribonucleotide reductase 00:08:10.25 and so there are two of them here 00:41:52.01 I told you what metalloproteins were, 00:41:48.27 Alright, so here was the outline that we had. 00:33:54.24 is a very common resolution for a protein structure, 00:17:50.10 we start to see what looks like ring structures. 00:16:18.08 again radical chemistry. 00:06:52.07 and the radical needs to move 00:33:38.17 and lighter atoms such as carbon. However, it is becoming increasingly clear that these divisions are somewhat artificial as there are a number of MMPs that do not fit into any of the traditional groups. 00:20:17.17 such as when you have polyethylene glycol around. DNA binding allosterically activates the cytosolic DNA sensor cGAS (cyclic GMP-AMP [cGAMP] synthase) to synthesize 2'3'-cGAMP, using Mg2+ as the metal cofactor that catalyzes two nucleotidyl-transferring reactions. 00:07:58.17 So, there's a structure of a methyltransferase from my lab,

00:09:12.23 Nucleic acid metabolism as well. 00:21:48.09 from the SAXS, 00:26:13.16 is that often you can't use sort of Coor, planar, trigonal or linear) can impart bias either in folded apopr, if the preformed site is rigid or during folding if favour, geometries of four divalent metals in proteins, metals is imperfect, especially in nascent polypeptides. 00:38:24.03 of a protein when you've destroyed the catalytic center 00:06:28.04 and it happens over this long distance, 00:16:23.24 with chlorine so it works as an anti-fungal agent, 00:06:08.13 So we need to fix nitrogen. 00:28:23.27 of the B12 cofactor and refine it, Whole-cell biosensors, which can proliferate independently, can detect the bioavailable fraction to assess the effect of target heavy metal on the environmental ecosystem. 00:16:08.20 and now the protective domain, in yellow, is behind, 00:24:04.27 "How would you explain this to a middle school audience?" 00:03:08.12 for RiboNucleotide Reductase. 00:20:34.20 We wanted to know what species are active. 00:01:12.20 I will tell you that that chemical prowess 00:42:13.03 and a little about how you can capture 00:32:36.02 that allowed us to characterize it, 00:06:53.28 from here up to here. 00:14:14.00 and by we I mean Michael Funk, a graduate student in the lab, 00:15:10.00 to get that reaction to go, 00:08:30.05 this enzyme needs to shake, rattle, and roll 00:20:27.01 Metals that are controlled is good. 00:22:34.19 sequestering it, converting it to something else. 00:02:35.17 to understand how they carry out their function. Evidence for the importance of Cu in natural communities of phytoplankton was obtained from an incubation experiment performed in the Fe-limited basin of the Bering Sea. 00:31:50.18 what do you see out of such a model? 00:17:59.17 And over here we just show what kinds 00:16:05.12 so here you see concentration-dependent behavior. 00:16:16.05 So what happens to this structure,

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